Equine Orthomix :: Veterinary Transplant Services

Many types of grafts available to match your specific need.

Equine Products

Osteoallograft^® Orthomix^®

Osteoallograft^® Periomix^®

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Osteoallograft^® Orthomix^® (Equine)

Product Description
Indications
Veterinarian and Patient Benefits
Product Specifications
Support Materials
Clinical References

Product Description

Osteoallograft^® Orthomix^® is natural, real bone allograft designed specifically for veterinary use. It consists of osteoinductive Demineralized Bone Matrix (DBM) and osteoconductive cancellous bone chips. Using bone allograft allows you to avoid autograft procurement and associated morbidity risks. Also, because it not only provides osteoconductive scaffold but also native, osteoinductive growth factors (BMPs), you will achieve faster and stronger bone healing compared with using bone substitutes. ¹

The demineralization of allograft during tissue processing allows for immediate access to the growth factors (BMPs) inherent in natural bone when it is placed into the surgery site. This results in an immediate beginning of the healing process and helps to make allograft as effective as autograft ^2-4

Osteoallograft^® Orthomix^® is professional-grade allograft:

• Processed aseptically meeting USP guidelines for sterility

•
Acellular and processed by methods that reduce immunogenicity, which eliminates concerns about immune reactions and the need for any type of patient matching

•
Our production practices are GMP and Good Tissue Practices compliant and modeled after human tissue banking standards

•
Our stringent Quality Assurance Program provides confidence and consistency in our products

Indications

Use Osteoallograft^® Orthomix^® for:
•	Fracture repair, any type of fracture including sesamoid & navicular
•	Arthrodesis procedures
•	Bone voids, cysts, and bone loss
•	Spinal fusions
•	Any other void filling or bone augmentation procedure that would benefit from grafting

Veterinarian and Patient Benefits

Why graft:
•	Bone will heal faster when voids are filled with bone graft, because it provides osteoconductive scaffold for host bone to grow on and native, osteoinductive BMPs that attract osteoblasts to the site. Even when there are no voids, bone graft provides these same advantages.^{2, 7-9} The structural strength of the graft can be expected to increase rapidly after the first 10 days.⁷
•	Faster healing not only gets your patients back to normal activity faster it also increases the chances of a successful healing outcome. ^{2, 7-9}

Why use allograft:
•	Reduces your OR time and cost, because it allows you to skip autograft harvesting ¹⁰
•	Eliminates morbidity risks associated with the collection of bone autograft. Studies show a morbidity rate of over 25% in humans ⁶
•	In many cases, allows you to use more bone graft than you can procure from the patient. Allograft can also be used to augment insufficient quantities of autograft.
•	Studies show that allografts are as effective as autograft in bone healing^2-4
•	Achieves faster and stronger bone healing than bone substitutes due to osteoinductive growth factors (BMPs) inherent in natural bone ¹

Product Specifications

Product Name:	Orthomix^®

Particle Size:	Demineralized Bone Matrix with cancellous chips < 2.3 mm
Indications:	Fracture repair Fill bone cysts Arthrodeses Bone loss cases
Preservation:	Freeze-Dried
Volumes Available:	3 cc 6 cc 15 cc coming soon
To use our Online Order Form, click here

Support Materials

Osteoallograft Orthomix Flyer (PDF: 594 KB)
Frequently Asked Questions (PDF: 111 KB)
Literature List with Excerpts (PDF: 173 KB)
A Word from the Director (PDF: 233 KB)
Pricelist (PDF: 734 KB)
Fax Order Form (PDF: 264 KB)
Online Order Form

Clinical References

1.	Griffon DJ, Dunlop DG, Howie CR, Gilchrist T, Salter DM, Healy DM. Early dissolution of a morsellised impacted silicate-free bioactive glass in metaphyseal defects. J Biomed Mater Res (Applied Biomater). 58(6): 638-644, 2001.
2.	Hoffer M, Griffon D, Schaeffer D, Johnson A, Thomas M. Clinical applications of demineralized bone matrix: A retrospective and case-matched study of 75 dogs. Vet Surg. 37: 639-647, 2008.
3.	Samartzis D, Shen FH, Matthews DK, Yoon ST, Goldberg EJ, An HS. Comparison of allograft to autograft in multilevel anterior cervical discectomy and fusion with rigid plate fixation. Spine J. Nov-Dec 3(6): 451-9, 2003.
4.	Piotrowski M, Pankowski R, Luczkiewicz P, Markowicz A. A comparison of the effect of autogenous vs. frozen homogenous grafts on the healing of non-union of forearm bones. Ortop Traumatol Rehabil. 10(2): 146-51, 2008.
5.	Fackelman G, Auer J. Bone graft biology and autogenous grafting in: AO Principles of Equine Osteosynthesis. Bramlage LR, et al., eds. AO Publishing, Davos Platz, pp. 323-332, 2000.
6.	Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma. 3(3): 192-195, 1989.
7.	Nunamaker DM. General techniques and biomechanics. in: AO Principles of Equine Osteosynthesis. Bramlage LR, et al;, eds. AO Publishing, Davos Platz, pp. 11-24, 2000.
8.	Douglas J, Clarke A. Response to demineralized bone matrix implantation in foals and adult horses. Am J Vet Res. 56(5): 649-55. 1995.
9.	DeVries WJ, Runyon CL, Martinez SA, Ireland WP. Effect of volume variations on osteogenic capabilities of autogenous cancellous bone graft in dogs. Am J Vet Res. Oct 57(10): 1501-1505, 1996.
10.	St John TA, Vaccaro AR, Sah AP, Schaefer M, Berta SC, Albert TA, Hilibrand A. Physical and monetary costs associated with autogenous bone graft harvesting. Am J Orthop. Jan 32(1): 18-23, 2003.

To see more references for use of bone graft in orthopedics, click here >>

Click on image to see a Grafting Options Comparison Chart

Nunamaker DM. General techniques and biomechanics. in: AO Principles of Equine Osteosynthesis. Bramlage LR, et al;, eds. AO Publishing, Davos Platz, pp. 11-24, 2000.

Douglas J, Clarke A. Response to demineralized bone matrix implantation in foals and adult horses. Am J Vet Res. 56(5): 649-55. 1995.

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