Osteoallograft^® Orthomix^®

Product Types   |   Indications   |   Benefits  |   How to Use   |   Videos   |   Case Studies   |   Brochures   |   References

Osteoallograft^® is the tried and true solution for natural bone healing and the BENCHMARK against which the performance of all other bone graft materials is measured.

Osteoallograft^® Orthomix^® is natural, real bone graft designed specifically for veterinary use. It consists of osteoinductive Demineralized Bone Matrix (DBM) and osteoconductive cancellous bone chips. The demineralization of graft allows for immediate access to the growth factors (BMPs) inherent in allograft bone when it is placed into the surgery site. This results in an early beginning of the healing process and helps to make allograft as effective as autograft.

Using bone allograft allows you to:

• Avoid harvesting autograft; saving time and morbidity risk.
• Increase the growth factors locally to facilitate bony healing. Particulate bone graft provides enormously more surface area with exposed BMP’s than the patient’s own fracture, arthrodesis or osteotomy site; resulting in an increase in exposure to growth factors inherent in the bone graft.
• Achieve faster and stronger bone healing compared with using bone substitutes, because it provides both an osteoconductive scaffold and also osteoinductive growth factors (BMPs).^1-5 No other bone graft substitute available on the market provides BOTH critical factors for speedy bone healing.

Product Types

Osteoallograft^® is professional-grade allograft:

• Processed aseptically meeting USP guidelines for sterility
• Acellular and processed by methods that reduce immunogenicity, which eliminates concerns about immune reactions and the need for any type of patient matching.
• Our production practices are GMP and Good Tissue Practices compliant and modeled after human tissue banking standards
• Our stringent Quality Assurance Program provides confidence and consistency in our products

Indications

Use Osteoallograft® Orthomix® for:

• Fracture repair
• Mal- or non-union cases
• Arthrodesis procedures
• Bone loss
• TTAs and TPLOs ^2,5
• Any other application where bone graft is needed

Veterinarian and Patient Benefits

Why graft:

• Bone will heal faster when voids are filled with bone graft, because it provides osteoconductive scaffold for host bone to grow on and native, osteoinductive BMPs that attract osteoblasts to the site. Even when there are no voids, bone graft provides these same advantages. ^2,6,7
• Faster healing not only gets your patients back to normal activity faster it also increases the chances of a successful healing outcome ^2,6,7

Why use allograft:

• Reduces your OR time and cost, because it allows you to skip autograft harvesting ⁸
• Eliminates morbidity risks associated with the collection of bone autograft. Studies show a morbidity rate of over 25% in humans ⁹
• In many cases, allows you to use more bone graft than you can procure from the patient. Allograft can also be used to augment insufficient quantities of autograft.
• Studies show that allografts are as effective as autograft in bone healing ^2-4
• Achieves faster and stronger bone healing than bone substitutes due to osteoinductive growth factors (BMPs) inherent in natural bone.¹ To see Grafting Options Comparison Chart, click here.

How To Use: Freeze-Dried Graft

How To Use: Frozen Graft

Product Handling Videos

Case Studies

• Orthomix & Segmental Allograft: Replacing Resorbed femoral section (Greenwood, “Juaquin”)
• Orthomix Case Studies: Fracture Repair (Gillis, “Xena”) Non-Union with Bone loss (Greenwood, “Delenn”)
• Orthomix Ultra-Fine: Arthrodesis (Hulse, “Will”)
• Orthomix Ultra-Fine: Fracture Repair (Gillis, “Xena”)
• Antibiotic Soak Kit & Orthomix: The Solution to Infection (Ailes, “Zorro”)

Brochures

• Osteoallograft Orthomix Brochure
• Use of VTS grafts in different species – Xenografts

References

1. Griffon DJ, Dunlop DG, Howie CR, Gilchrist T, Salter DM, Healy DM. Early dissolution of a morsellised impacted silicate-free bioactive glass in metaphyseal defects. J Biomed Mater Res (Applied Biomater). 58(6):638-644, 2001.
2. Hoffer M, Griffon D, Schaeffer D, Johnson A, Thomas M. Clinical applications of demineralized bone matrix: A retrospective and case-matched study of 75 dogs. Vet Surg. 37:639-647, 2008.
3. Samartzis D, Shen FH, Matthews DK, Yoon ST, Goldberg EJ, An HS. Comparison of allograft to autograft in multilevel anterior cervical discectomy and fusion with rigid plate fixation. Spine J. Nov-Dec 3(6): 451-9, 2003.
4. Piotrowski M, Pankowski R, Luczkiewicz P, Markowicz A. A comparison of the effect of autogenous vs. frozen homogenous grafts on the healing of non-union of forearm bones. Ortop Traumatol Rehabil. 10(2):146-51, 2008.
5. Lafaver S, Miller NA, Stubbs WP, Taylor RA, Boudrieau RJ. Tibial tuberosity advancement for stabilization of the canine cranial cruciate ligament-deficient stifle joint: surgical technique, early results, and complications in 101 dogs. Veterinary Surgery. 36:573-586, 2007.
6. Kesemenli CC, Kapukaya A, Subasi M, Arslan H, Necmioglu S, Kayikci C. Early prophylactic autogenous bone grafting in type III open tibial fractures. Acta Orthop Belg. 70(4):327-31, 2004.
7. DeVries WJ, Runyon CL, Martinez SA, Ireland WP. Effect of volume variations on osteogenic capabilities of autogenous cancellous bone graft in dogs. Am J Vet Res. Oct 57(10):1501-1505, 1996.
8. St John TA, Vaccaro AR, Sah AP, Schaefer M, Berta SC, Albert TA, Hilibrand A. Physical and monetary costs associated with autogenous bone graft harvesting. Am J Orthop. Jan 32(1):18-23, 2003.
9. Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma. 3(3):192-195, 1989.

To see more references for use of bone graft in orthopedics, click here >>